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pentobarbital will raise the level or impact of ivosidenib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of ivosidenib with solid CYP3A4 inducers lowered ivosidenib plasma concentrations.This drug could raise the metabolism of estradiol when administered concurrently; clients on o